APOE遺伝子型と病理負荷から読み解くレビー小体病の認知症発症メカニズム

MedAI Digest (JA)
MedAI Digest (JA)
APOE遺伝子型と病理負荷から読み解くレビー小体病の認知症発症メカニズム
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レビー小体病において、APOE遺伝子型は認知症発症の個別的な病理閾値を決定し、APOE ε3とε4キャリアでは異なるリスク構造を示す。定量的病理測定は従来の病理学的段階分類より認知症予測性能が優れている。

Original paper: Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease. — Brain : a journal of neurology. 10.1093/brain/awag114

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