APOE基因型如何决定路易体病患者的痴呆风险：一项大规模病理学研究

MedAI Digest (ZH)
MedAI Digest (ZH)
APOE基因型如何决定路易体病患者的痴呆风险：一项大规模病理学研究
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路易体病是神经退行性疾病的常见病因，但同样的脑部病理改变为何会导致患者痴呆程度差异悬殊？一项整合APOE基因型和量化病理分析的研究发现，患者的遗传背景在很大程度上决定了他们对α-突触核蛋白沉积的”容受度”，从而开启了精准医学干预的新思路。

Original paper: Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease. — Brain : a journal of neurology. 10.1093/brain/awag114

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