血液蛋白质组学精准检测唐氏综合征患者脑淀粉样蛋白沉积

MedAI Digest (ZH)
MedAI Digest (ZH)
血液蛋白质组学精准检测唐氏综合征患者脑淀粉样蛋白沉积
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一项新研究在290名成年唐氏综合征患者中发现，通过血液蛋白质组学检测可以以96%的准确度识别脑部淀粉样蛋白沉积，而患者的APOE ε4等位基因携带状态对检测效能影响极小。

Original paper: The association between APOE 𝜀4 carrierships and the detection of amyloid positivity using an Alzheimer’s disease proteomic blood test in asymptomatic Down syndrome. — Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 10.1002/alz.71338

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