Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124
Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124

A 399-case postmortem study reveals APOE genotype fundamentally alters how Lewy body pathology drives dementia risk, with ε3 and ε4 carriers showing distinct disease trajectories. Background Lewy body diseases cause significant neurodegeneration but predicting dementia risk remains challenging. Researchers analyzed…

A landmark post-mortem study uncovers APOE as the critical factor in dementia risk for Lewy body disease—and the finding breaks down neatly: ε3 and ε4 carriers follow entirely different rules about how much protein pathology their brains can tolerate before…