仅用肿瘤样本也能精准诊断——深度学习模型VarNet-T改革肿瘤突变检测

MedAI Digest (ZH)
MedAI Digest (ZH)
仅用肿瘤样本也能精准诊断——深度学习模型VarNet-T改革肿瘤突变检测
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VarNet-T是一种新型深度学习框架,能够在仅有肿瘤样本的情况下准确识别体细胞变异并估计肿瘤突变负荷(TMB),相比现有方法性能提升20-33%,有望改善癌症患者的免疫疗法精准筛选。

Original paper: Improved tumor-only variant calling and mutation burden estimation with VarNet-T. — Nature communications. 10.1038/s41467-026-71705-4

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