APOE Genotype and Protein Pathology Shape Dementia Risk in Lewy Body Disease

MedAI Digest
MedAI Digest
APOE Genotype and Protein Pathology Shape Dementia Risk in Lewy Body Disease
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A landmark post-mortem study uncovers APOE as the critical factor in dementia risk for Lewy body disease—and the finding breaks down neatly: ε3 and ε4 carriers follow entirely different rules about how much protein pathology their brains can tolerate before cognitive decline sets in.

Original paper: Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease. — Brain : a journal of neurology. 10.1093/brain/awag114

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